Development and Characterization of Mupirocin Emulgel for the Treatment of Primary and Secondary Infections in Dry Skin Conditions

Background: Dry skin conditions’ primary and secondary infections can be treated by using mupirocin topically. By overcoming the disadvantages of ointments, creams, lotions, goal formulation emulgel was to improve occlusive properties gels topical delivery hydrophobic drugs with favorable for dry conditions, as well investigate impact concentration different gelling agents (carbopol 940, carbopol 934, xanthum gum) on viscosity drug release prepared. Materials Methods: Oil, an emulsifier, a co surfactant, three types agents, such Carbopol gum, were used make emulgel. The physical characteristics, pH measurement, spreadability, content, rheological study, in vitro each prepared evaluated. Researchers also looked at sensitivity, ex vivo penetration retention, antibacterial effectiveness, stability formulation. Results: Excellent homogeneity, acceptable pH, medication consistency all features newly developed emugels. made 934 (0.8 percent w/w), which is F4 batch, demonstrated greatest 82.54±0.39 optimal 4117.0± 0.59 among formulations. improved had good activity, stable, didn’t irritate skin, exhibited retention skin. Conclusion: results show that designed successfully integrated into various inversely related viscosity.